NEWS

Japanese Society for Regenerative Medicine Announces the YOKOHAMA Declaration 2025
—Committing to Scientific Rigor and Ethical Responsibility in Regenerative Medicine—

Tokyo, Japan —March 19, 2025— The Japanese Society for Regenerative Medicine (JSRM), Japan’s leading scientific organization dedicated to advancing regenerative medicine, today announced the adoption of the “YOKOHAMA Declaration 2025” during its 24th Annual Meeting, held in Yokohama, Japan.
In response to growing international concerns about the proliferation of unverified regenerative medicine practices provided under Japan’s Act on the Safety of Regenerative Medicine (ASRM), JSRM recognizes its responsibility to clearly differentiate scientifically valid treatments from those lacking sufficient scientific scrutiny.

The Declaration explicitly distinguishes:

• Explorative Therapy:
  Therapy using processed cells or nucleic acids, etc. for which a manufacturing and marketing approval has not been obtained under PMD Act, and for which clinical data are accumulated in an independent third-party registry and an Explorative Study is conducted both prior to and following the treatment
• Uninvestigated Therapy:
  Therapy not qualified as “Explorative Therapies,” by using processed cells or nucleic acids, etc. for which a manufacturing and marketing approval has not been obtained under PMD Act

Through this Declaration, JSRM commits to promoting active dialogue with patients, the general public, and medical professionals engaged in clinical practice, to enhance awareness and accurate understanding of approved treatments and unapproved regenerative medical practices.

The Society further commits to developing practical guidelines that ensure transparency, patient protection, and scientific integrity within the field of regenerative medicine in Japan.

For more information, please refer to the full text of the YOKOHAMA Declaration 2025 (The English version begins on page 3)

Media Contact:
Foreign Affairs Office
Email: foreignaffairs@jsrm.jp